文献类型： 外文期刊
作者： Li, Shu 1 ; Liu, Gongyan 2 ; Liu, Lei 1 ; Li, Fuchang 1 ;
作者机构： 1.Shandong Agr Univ, Dept Anim Sci, Shandong Prov Key Lab Anim Biotechnol & Dis Contr, Tai An, Peoples R China
2.Shandong Acad Agr Sci, Inst Anim Husb & Vet Med, Jinan, Peoples R China
关键词： hair follicle development; heat shock; methionine; rabbit; signaling pathway
期刊名称：FASEB JOURNAL （ 影响因子：5.834； 五年影响因子：6.103 ）
ISSN： 0892-6638
年卷期： 2022 年 36 卷 8 期
页码：
收录情况： SCI
摘要： In the present experiment, we study the function of methionine on hair follicle development in heat-stressed Rex Rabbits and its potential molecular mechanism. Rex rabbits were randomly divided into 5 groups (30 replicates per group): control group (20-25 degrees C, fed basic diet), heat stress group (30-34 degrees C, fed basic diet), heat stress + methionine group (30-34 degrees C, fed 0.15% methionine in addition to the basic diet). fed basic diet (control), heat stress + methionine group (30-34 degrees C, fed 0.3% methionine in addition to the basic diet), heat stress + methionine group (30-34 degrees C, fed 0.45% methionine in addition to the basic diet). The results show that heat stress decreases the hair follicle density of Rex rabbits, and the diet methionine addition significantly increases the hair follicle density of heat-stressed Rabbits (p < .05). Heat stress increased serum HSP70 concentration and skin HSP70 gene expression, 0.15%-0.3% methionine but not 0.45% addition alleviated the effect of heat stress. Dietary 0.15% methionine addition significantly increases the gene expression of Wnt10b, beta-catenin, LEF, FZD4, LRP6, Shh, HGF, EGF, and Noggin in heat-stressed Rex rabbits and observably decreases the gene expression of BMP2/4 and TGFb. There was no significant effect of methionine on the expression of IGF1 and FGF5/7 gene expression. In conclusion, methionine maybe promotes hair follicle development via TGF beta-BMP/Shh-Noggin, Wnt10b/beta-catenin, EGF, and HGF signaling pathways in heat-stressed rabbits.
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