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Functional evaluation of the insulin/insulin-like growth factor signaling pathway in determination of wing polyphenism in pea aphid

文献类型： 外文期刊

作者： Yuan, Yiyang 1 ; Wang, Yanyan 2 ; Ye, Wanwan 2 ; Yuan, Erliang 2 ; Di, Jian 2 ; Chen, Xin 5 ; Xing, Yanling 5 ; Sun, Yucheng 2 ; Ge, Feng 1 ;

作者机构： 1.Shandong Acad Agr Sci, Inst Plant Protect, Jinan 250100, Peoples R China

2.Chinese Acad Sci, Inst Zool, State Key Lab Integrated Management Pest Insects, Beijing 100101, Peoples R China

3.Shandong Prov Key Lab Plant Virol, Jinan, Peoples R China

4.Hebei Univ, Sch Life Sci, Baoding, Hebei, Peoples R China

5.Cangzhou Normal Univ, Coll Life Sci, Cangzhou, Hebei, Peoples R China

关键词： Acyrthosiphon pisum; FoxO; insulin; insulin-like growth factor signaling pathway; insulin-like peptides; wing polyphenism

期刊名称：INSECT SCIENCE （ 影响因子：3.605； 五年影响因子：3.323 ）

ISSN： 1672-9609

年卷期：

页码：

收录情况： SCI

摘要： Wing polyphenism is a common phenomenon that plays key roles in environmental adaptation of insects. Insulin/insulin-like growth factor signaling (IIS) pathway is a highly conserved pathway in regulation of metabolism, development, and growth in metazoans. It has been reported that IIS is required for switching of wing morph in brown planthopper via regulating the development of the wing pad. However, it remains elusive whether and how IIS pathway regulates transgenerational wing dimorphism in aphid. In this study, we found that pairing and solitary treatments can induce pea aphids to produce high and low percentage winged offspring, respectively. The expression level of ILP5 (insulin-like peptide 5) in maternal head was significantly higher upon solitary treatment in comparison with pairing, while silencing of ILP5 caused no obvious change in the winged offspring ratio. RNA interference-mediated knockdown of FoxO (Forkhead transcription factor subgroup O) in stage 20 embryos significantly increased the winged offspring ratio. The results of pharmacological and quantitative polymerase chain reaction experiments showed that the embryonic insulin receptors may not be involved in wing polyphenism. Additionally, ILP4 and ILP11 exhibited higher expression levels in 1st wingless offspring than in winged offspring. We demonstrate that FoxO negatively regulates the wing morph development in embryos. ILPs may regulate aphid wing polyphenism in a developmental stage-specific manner. However, the regulation may be not mediated by the canonical IIS pathway. The findings advance our understanding of IIS pathway in insect transgenerational wing polyphenism.

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