Polymorphisms of MASP2 gene and its relationship with mastitis and milk production in Chinese Holstein cattle
文献类型： 外文期刊
作者： Zhang, Haiyan 1 ; Wei, Yan 1 ; Zhang, Fengying 1 ; Liu, Yanyan 1 ; Li, Yan 1 ; Li, Ge 1 ; Han, Bing 1 ; Wang, Haifeng 1 ; Zh 1 ;
作者机构： 1.Heze Med Coll, Dept Biochem, Heze, Shandong, Peoples R China
2.Shandong Acad Agr Sci, Dairy Cattle Res Ctr, 159 Ind North Rd, Jinan 250131, Shandong, Peoples R China
关键词： MASP2; polymorphisms; mastitis; CH50; SCS
期刊名称：BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT （ 影响因子：1.632； 五年影响因子：2.029 ）
ISSN： 1310-2818
年卷期：
页码：
收录情况： SCI
摘要： Mastitis is a deleterious disease of dairy cattle, and its incidence is closely related with the innate immune response, including the complement system. Mannose-binding lectin-associated serine protease 2 (MASP2) is a functional central enzyme in the complement system. Here, we aimed to study single nucleotide polymorphisms (SNPs) of MASP2 and its relationship with mastitis and milk production in Chinese Holstein cattle. We found three novel SNPs, namely g.14047A > C, g.14248T > C and g.14391C > T, in MASP2. The SNP g.14047 A > C (GAA (Glu) > GAC (Asp)) at position 608aa of MASP2 was correlated with the CH50 level and the protein percentage. Meanwhile, the SNP g.14248 T > C (ATT (Ile) > ATC (Ile)) at position 675aa was also correlated with the CH50 value and the milk production. The haplotype combinations H2H2 and H2H4 showed a significant relationship with the CH50, SCS and the milk production abilities, respectively. Based on the SNPs identified in this gene, several genotypes and haplotypes, respectively, were found in Chinese Holstein cattle. The genotypes AC (g.14047 A > C) and TT (g.14248 T > C) and the haplotype combinations H2H2 and H2H4 may be used as molecular markers for breeding mastitis-resistant dairy cattle. The haplotype combination H1H2 should be gradually phased out in breeding programmes.
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