文献类型： 外文期刊
作者： Han, Tongwen 1 ; Wang, Fang 1 ; Song, Qingxin 1 ; Ye, Wenxue 1 ; Liu, Tieshan 2 ; Wang, Liming 2 ; Chen, Z. Jeffrey 3 ;
作者机构： 1.Nanjing Agr Univ, State Key Lab Crop Genet & Germplasm Enhancement, 1 Weigang Rd, Nanjing 210095, Peoples R China
2.Shandong Acad Agr Sci, Maize Res Inst, Jinan 250100, Peoples R China
3.Univ Texas Austin, Dept Mol Biosci, Austin, TX 78712 USA
4.Univ Texas Austin, Ctr Computat Biol & Bioinformat, Austin, TX 78712 USA
期刊名称：SCIENCE ADVANCES （ 影响因子：14.143； 五年影响因子：16.45 ）
ISSN： 2375-2548
年卷期： 2021 年 7 卷 35 期
页码：
收录情况： SCI
摘要： Inbreeding depression is widespread across plant and animal kingdoms and may arise from the exposure of deleterious alleles and/or loss of overdominant alleles resulting from increased homozygosity, but these genetic models cannot fully explain the phenomenon. Here, we report epigenetic links to inbreeding depression in maize. Teosinte branched1/cycloidea/proliferating cell factor (TCP) transcription factors control plant development. During successive inbreeding among inbred lines, thousands of genomic regions across TCP-binding sites (TBS) are hypermethylated through the H3K9me2-mediated pathway. These hypermethylated regions are accompanied by decreased chromatin accessibility, increased levels of the repressive histone marks H3K27me2 and H3K27me3, and reduced binding affinity of maize TCP-proteins to TBS. Consequently, hundreds of TCP-target genes involved in mitochondrion, chloroplast, and ribosome functions are down-regulated, leading to reduced growth vigor. Conversely, random mating can reverse corresponding hypermethylation sites and TCP-target gene expression, restoring growth vigor. These results support a unique role of reversible epigenetic modifications in inbreeding depression.
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