Prodigiosin of Serratia marcescens ZPG19 Alters the Gut Microbiota Composition of Kunming Mice
文献类型： 外文期刊
作者： Li, Xue 1 ; Tan, Xinfeng 1 ; Chen, Qingshuang 1 ; Zhu, Xiaoling 2 ; Zhang, Jing 1 ; Zhang, Jie 1 ; Jia, Baolei 1 ;
作者机构： 1.Qilu Univ Technol, Shandong Acad Sci, Sch Bioengn, State Key Lab Biobased Mat & Green Papermaking, Jinan 250000, Peoples R China
2.Shandong Acad Agr Sci, Jinan 250000, Peoples R China
关键词： gut microbiota; Kunming mice; pathologic visceral changes; prodigiosin; Serratia marcescens
期刊名称：MOLECULES （ 影响因子：3.267； 五年影响因子：3.589 ）
ISSN：
年卷期： 2021 年 26 卷 8 期
页码：
收录情况： SCI
摘要： Prodigiosin is a red pigment produced by Serratia marcescens with anticancer, antimalarial, and antibacterial effects. In this study, we extracted and identified a red pigment from a culture of S. marcescens strain ZPG19 and investigated its effect on the growth performance and intestinal microbiota of Kunming mice. High-performance liquid chromatography/mass spectrometry revealed that the pigment had a mass-to-charge ratio (m/z) of 324.2160, and thus it was identified as prodigiosin. To investigate the effect of prodigiosin on the intestinal microbiota, mice (n = 5) were administered 150 mu g/kg/d prodigiosin (crude extract, 95% purity) via the drinking water for 18 days. Administration of prodigiosin did not cause toxicity in mice. High-throughput sequencing analysis revealed that prodigiosin altered the cecum microbiota abundance and diversity; the relative abundance of Desulfovibrio significantly decreased, whereas Lactobacillus reuteri significantly increased. This finding indicates that oral administration of prodigiosin has a beneficial effect on the intestinal microbiota of mice. As prodigiosin is non-toxic to mouse internal organs and improves the mouse intestinal microbiota, we suggest that it is a promising candidate drug to treat intestinal inflammation.
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