文献类型： 外文期刊
作者： Yu, Jin-Hai 1 ; Yu, Shu-Juan 1 ; Liu, Kai-Lu 1 ; Wang, Chao 1 ; Liu, Chao 2 ; Sun, Jin-yue 2 ; Zhang, Hua 1 ;
作者机构： 1.Jinan Univ, Sch Biol Sci & Technol, Jinan 250022, Peoples R China
2.Shandong Acad Agr Sci, Inst Agrofood Sci & Technol, Jinan 250100, Peoples R China
关键词： Ganoderma lingzhi; Lingzhi; Ergostane; Steroids; Cytotoxicity
期刊名称：STEROIDS （ 影响因子：2.668； 五年影响因子：2.692 ）
ISSN： 0039-128X
年卷期： 2021 年 165 卷
页码：
收录情况： SCI
摘要： Two new ergostane-type steroids (1 and 2) have been isolated from the fruiting body of a medicinal macro fungus Ganoderma lingzhi. The structures including the absolute configurations of them were elucidated by a combination of different spectroscopic analyses especially C-13 NMR and ECD calculations. Compound 2 features an unusual 1,2-dioxolane moiety. Our bioassays revealed that the two steroids showed remarkable cytotoxicity against human A549 (lung) and MCF-7 (breast) tumor cell lines, with IC50 values ranging from 5.15 to 8.57 mu g/mL.
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