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Heat stress decreases egg production of laying hens by inducing apoptosis of follicular cells via activating the FasL/Fas and TNF-alpha systems

文献类型： 外文期刊

作者： Li, Gui-Ming 1 ; Liu, Li-Ping 2 ; Yin, Bin 2 ; Liu, Yue-Yue 2 ; Dong, Wen-Wen 2 ; Gong, Shuai 1 ; Zhang, Jie 1 ; Tan, Jin 1 ;

作者机构： 1.Shandong Agr Univ, Coll Anim Sci & Vet Med, Shandong Prov Key Lab Anim Biotechnol & Dis Contr, Tai An, Shandong, Peoples R China

2.Shandong Acad Agr Sci, Inst Poultry Sci, Jinan, Shandong, Peoples R China

关键词： heat stress; follicular cell apoptosis; FasL/Fas signaling; TNF-alpha signaling; laying hen

期刊名称：POULTRY SCIENCE （ 影响因子：3.352； 五年影响因子：3.679 ）

ISSN：

年卷期： 2020 年 99 卷 11 期

页码：

收录情况： SCI

摘要： Heat stress (HS) causes significant economic losses in the poultry industry every year. However, the mechanisms for the adverse effects of HS on avian follicular development are largely unknown. The aim of this study was to test whether HS induces apoptosis of follicular cells and impairs egg production by activating the FasL/Fas and tumor necrosis factor (TNF)-alpha systems. To this end, Hy-Line Brown laying hens, at 32 wk of age, were either exposed to HS of 35 degrees C to 37 degrees C or maintained at 24 degrees C to 26 degrees C (control) for 5 D. At the end of the HS period, follicle numbers, apoptosis, FasL/Fas and TNF-alpha activation, oxidative stress, and hormone secretion were examined in ovarian follicles. Egg production was observed daily during both the stressed (day S1-S5) and the poststress recovery (day R1-R15) periods. The results demonstrated that HS on hens significantly 1) decreased laying rates from day S3 to R6; 2) reduced numbers of large yellow and hierarchical follicles; 3) triggered apoptosis while increasing the expression of FasL, Fas, TNF-alpha, and TNF-receptor 1 in small and large yellow follicles; and 4) increased levels of oxidative stress, corticotrophin-releasing hormone, and corticosterone while decreasing the estradiol/progesterone ratio in follicular fluid in small and large yellow follicles. Taken together, the results suggested that hen HS impaired egg production by reducing the number of follicles through inducing apoptosis and that it triggered apoptosis in follicular cells by activating the FasL/Fas and TNF-alpha systems.

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