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The Age-Accompanied and Diet-Associated Remodeling of the Phospholipid, Amino Acid, and SCFA Metabolism of Healthy Centenarians from a Chinese Longevous Region: A Window into Exceptional Longevity

文献类型： 外文期刊

作者： Cai, Da 1 ; Zhao, Zimo 2 ; Zhao, Lingjun 3 ; Dong, Yanjie 1 ; Wang, Lei 1 ; Zhao, Shancang 1 ; Li, Quanyang 4 ;

作者机构： 1.Shandong Acad Agr Sci, Inst Qual Stand & Testing Technol Agroprod, Shandong Prov Key Lab Test Technol Food Qual & Sa, Jinan 250100, Peoples R China

2.Univ Melbourne, Coll Vet & Agr Sci, Melbourne, Vic 3000, Australia

3.Jinan Agrotech Extens & Serv Ctr, Jinan 250004, Peoples R China

4.Guangxi Univ, Coll Light Ind & Food Engn, Nanning 530004, Peoples R China

关键词： centenarian; metabolomics; remodeling; phospholipid; amino acid; SCFA; dietary fiber; longevous region

期刊名称：NUTRIENTS （ 影响因子：6.706； 五年影响因子：7.185 ）

ISSN：

年卷期： 2022 年 14 卷 20 期

页码：

收录情况： SCI

摘要： As centenarians provide a paradigm of healthy aging, investigating the comprehensive metabolic profiles of healthy centenarians is of utmost importance for the pursuit of health and longevity. However, relevant reports, especially studies considering the dietary influence on metabolism, are still limited, mostly lacking the guidance of a model of healthy aging. Therefore, exploring the signatures of the integrative metabolic profiles of the healthy centenarians from a famous longevous region, Bama County, China, should be an effective way. The global metabolome in urine and the short-chain fatty acids (SCFAs) in the feces of 30 healthy centenarians and 31 elderly people aged 60-70 from the longevous region were analyzed by non-targeted metabolomics combined with metabolic target analysis. The results showed that the characteristic metabolites related to longevity were mostly summarized into phosphatidylserine, lyso-phosphatidylethanolamine, phosphatidylcholine, phosphatidylinositol, bile acids, and amino acids (p < 0.05). Six metabolic pathways were found significant relevant to longevity. Furthermore, acetic acid, propionic acid, butyric acid, valeric acid, and total SCFA were significantly increased in the centenarian group (p < 0.05) and were also positively associated with the dietary fiber intake (p < 0.01). It was age-accompanied and diet-associated remodeling of phospholipid, amino acid, and SCFA metabolism that expressed the unique metabolic signatures related to exceptional longevity. This metabolic remodeling is suggestive of cognitive benefits, better antioxidant capacity, the attenuation of local inflammation, and health-span-promoting processes, which play a critical and positive role in shaping healthy aging.

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