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Anti-angiogenic activity and mechanism of a chemically sulfated natural glucan from Phellinus ribis

文献类型： 外文期刊

作者： Liu, Yuhong 1 ; Xu, Jiazhen 1 ; Zong, Aizhen 2 ; Wang, Jihui 3 ; Liu, Yuguo 4 ; Jia, Wei 1 ; Jin, Juan 1 ; Yan, Guangling 1 ; Zhang, Yongqing 1 ;

作者机构： 1.Shandong Univ Tradit Chinese Med, Sch Pharmaceut Sci, Jinan 250355, Shandong, Peoples R China

2.Shandong Acad Agr Sci, Inst Agrofood Sci Technol, Jinan 250100, Shandong, Peoples R China

3.Shandong Univ Tradit Chinese Med, Comprehens Teaching Expt Ctr, Jinan 250355, Shandong, Peoples R China

4.Shandong Tumor Hosp, Dept Pharm, Jinan 250117, Shandong, Peoples R China

关键词： Sulfated polysaccharide; Phellinus ribis; Anti-angiogenic activity

期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：6.953； 五年影响因子：6.737 ）

ISSN： 0141-8130

年卷期： 2018 年 107 卷

页码：

收录情况： SCI

摘要： A sulfated polysaccharide named PRP-S16 was obtained by sulfation of a glucan from Phellinus ribis using the chlorosulfonic acid method. PRP-S16 could significantly block the formation of new vessels in chicken chorioallantoic membrane (CAM). It could also inhibit the proliferation, migration, and tube formation and significantly reduced the mRNA expression of vascular endothelial growth factor (VEGF) in EA.hy926 endothelial cells. Western blotting indicated that PRP-S16 down regulated the protein expression of VEGF and VEGF receptor-1 (VEGFR-1), and inhibited the phosphorylation of VEGFR-2, protein kinase B (Akt) and extracellular signal-regulated kinase (ERK1/2) in EA.hy926 cells. These findings suggest that the mechanism of action of the anti-angiogenesis activity of PRP-S16 is related to the inhibition of VEGF-induced signaling pathway. PRP-S16 might be utilized as an effective antagonist in combating diseases associated with angiogenesis. (C) 2017 Elsevier B.V. All rights reserved.

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