Comparison of the cross-protection of PPRSV sublineage 8.7 MLV vaccines against the recombinant NADC30-like strain
文献类型： 外文期刊
作者： Li, Jianda 1 ; Meng, Kai 3 ; Wang, Yu 1 ; Wang, Zhao 4 ; Peng, Jun 5 ; Ren, Sufang 1 ; Zhang, Yuyu 1 ; Guo, Lihui 1 ; Liu, Fei 1 ; Lv, Tingting 1 ; Jiao, Jian 1 ; Liu, Yanyan 1 ; Chen, Zhi 1 ; Sun, Wenbo 1 ; Yang, Guiwen 2 ; Yu, Jiang 1 ; Wu, Jiaqiang 1 ;
作者机构： 1.Shandong Acad Agr Sci, Inst Anim Sci & Vet Med, Shandong Key Lab Anim Dis Control & Breeding, Jinan 250100, Peoples R China
2.Shandong Normal Univ, Sch Life Sci, Jinan 250014, Peoples R China
3.Shandong Acad Agr Sci, Inst Poultry Sci, Poultry Breeding Engn Technol Ctr Shandong Prov, Shandong Key Lab Poultry Dis Diag & Immunol, Jinan 250023, Peoples R China
4.Shandong First Med Univ, Shandong Acad Med Sci, Sch Lab Anim & Shandong Lab Anim Ctr, Jinan 250000, Peoples R China
5.Shandong Agr Univ, Coll Anim Sci & Technol, Tai An 271018, Peoples R China
关键词： PRRSV; NADC30-like strain; Modified-live virus vaccine; Cross-protection; Epidemiology
期刊名称：VETERINARY MICROBIOLOGY （ 影响因子：3.3； 五年影响因子：3.5 ）
ISSN： 0378-1135
年卷期： 2023 年 281 卷
页码：
收录情况： SCI
摘要： The emergence of recombinant porcine reproductive and respiratory syndrome virus (PRRSV) has caused a substantial threat to the swine industry in recent years. However, the protective efficacy of different sublineage 8.7 PRRSV modified-live virus (MLV) vaccines against emerging strains were still obscure. In this study, a broad epidemiological investigation of PRRSV showed the prevalence of NADC30-like strain increased in Shandong Province, China from 2018 to 2020. Through piglet trial for vaccination and challenge with recombinant NADC30-like SDlz1601 strain, CH-1R MLV vaccine showed better protective effect than JXA1-R and TJM-F92 MLV vaccines in terms of clinical score and pathological observation. Moreover, all three MLV vaccines could reduce virus loads in the serum of piglets. This study provides valuable insights into the prevalence of the NADC30-like strain and the protective effect of PRRS MLV vaccines against recombinant NADC30-like strains, which could help to improve the prevention and control of PRRSV infections.
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