Porcine Reproductive and Respiratory Syndrome Virus Antagonizes JAK/STAT3 Signaling via nsp5, Which Induces STAT3 Degradation

Zhang, Yan-Jin; Wang, Rong; Xiao, Yueqiang; Nan, Yuchen; Wang, Yu; SCI

机构： Univ Maryland, VA MD Coll Vet Med, Mol Virol Lab, College Pk, MD 20742 USA; Univ Maryland, Maryland Pathogen Res Inst, College Pk, MD 20742 USA; Xi An Jiao Tong Univ, Sch Med, Lab Anim Ctr, Xian, Shaanxi, Peoples R China; Shandong Acad Agr Sci, Shandong Binzhou Anim Sci & Vet Med Acad, Binzhou Branch, Binzhou, Shandong, Peoples R China; Northwest A&F Univ, Coll Vet Med, Dept Vet Prevent Med, Yangling, Shaanxi, Peoples R China; Taishan Med Univ, Coll Basic Med Sci, Tai An, Shandong, Peoples R China;

关键词： porcine reproductive and respiratory syndrome virus (PRRSV) signal transducer and activator of transcription 3 STAT3 JAK/STAT signaling innate immunity PRRSV nsp5