A PB1 T296R substitution enhance polymerase activity and confer a virulent phenotype to a 2009 pandemic H1N1 influenza virus in mice

Yu, Zhijun; Qin, Chuan; Xia, Xianzhu; Yu, Zhijun; Qin, Chuan; Xia, Xianzhu; Yu, Zhijun; Sun, Weiyang; Zhang, Xinghai; Li, Yuanguo; Wang, Tiecheng; Wang, Hualei; Xin, Yue; Li, Xue; Zhang, Kun; Huang, Jing; Yang, Songtao; Gao, Yuwei; Xia, Xianzhu; Cheng, Kaihui; Zhang, Qianyi; Chen, Hualan; Wilker, Peter R.; Yue, Donghui; Gao, Yuwei; Xia, Xianzhu; Xia, Xianzhu; SCI

机构： Chinese Acad Med Sci, Inst Lab Anim Sci, Beijing 100021, Peoples R China; Peking Union Med Coll, Beijing 100021, Peoples R China; Acad Mil Med Sci, Mil Vet Res Inst, Key Lab Jilin Prov Zoonosis Prevent & Control, Changchun 130122, Peoples R China; Acad Mil Med Sci, Mil Vet Res Inst, Key Lab ;

关键词： Influenza A virus H1N1 Mouse model Virulence