Design and synthesis of pregnenolone/2-cyanoacryloyl conjugates with dual NF-kappa B inhibitory and anti-proliferative activities

Song, Jia-Li; Zhu, Kong-Kai; Yang, Fei-Fei; Liu, Xi-Gong; Zhang, Yu-Ying; Jiang, Cheng-Shi; Zhang, Hua; Zhang, Juan; Longo, Joao Paulo Figueiro; Muehlmann, Luis Alexandre; Zhang, Juan; Longo, Joao Paulo Figueiro; Muehlmann, Luis Alexandre; Azevedo, Ricardo Bentes; Liu, Chang-Liang; Liu, Chao; Guo, Yue-Wei; SCI

机构： Univ Jinan, Sch Biol Sci & Technol, Jinan 250022, Shandong, Peoples R China; Univ Brasilia, Fac Ceilandia, BR-72220275 Brasilia, DF, Brazil; Univ Brasilia, Inst Biol Sci, BR-70910900 Brasilia, DF, Brazil; Harvard Med Sch, Dept Neurobiol, Bost;

来源：BIOORGANIC & MEDICINAL CHEMISTRY LETTERS年份：2017

关键词： Pregnenolone NF-kappa B 2-Cyanoacryloyl Michael acceptor Anti-proliferative activity